Fournier's gangrene is a life - threatening necrotizing infection of the perineal, perianal, and periurethral tissues that can disseminate even at the subcutaneous tissue of the thigh or the abdomen following the planes of the fascia of the scrotum and penis. Despite the intensive care, the mortality is now still relative high. The study conducted at Viet-Duc Hospital, and reviewed the literature to find out the factor affected to the prognosis as elderly patients over 60 years old, alcoholism, associated diseases especially diabetes mellitus and cardiovascular problems, wide variety pathogens isolated and antibiotic resistance, severity of necrotizing as well as it's management. A multidisciplinary approach should always be considered for the efficient management of the clinical condition, which can help to reduce the mortality.
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