Nghiên cứu bào chế viện nén rã nhanh metoclopramid 10 mg

Regarding that (1) orally disintegrating tablets (ODTs) are claimed to be better soluble than conventional solid oral dosage forms, as the latter create problems for pediatric, geriatric, bedridden, nauseous or non-compliant patients, (2) the ODTs would be preferred by the patients in emetic conditions due to its administration without aid of water, and (3) conveniently consumed during traveling, this study undertook formulating ODTs of metoclopramide HCI (as an anti-emetic) of intermediate disintegration in the oral cavity without water within a matter of seconds, and furthermore improving the dissolution rate and drug bioavailability and onset of pharmacological action; thus, metoclopramid 10 mg tablets were prepared by direct compression. The formulation experimental plan was designed by Design Expert 8.0 software and optimized by the BC PharSoft software. Metoclopramid tablets prepared from the optimal fomula showed the disintegration time less than 20 seconds and met in-house specifications. The orally desintegrating tablets of metoclopramid, HCI 10 mg were successfully prepared at of 10,000 tablets scale and potentially produced at industrial scale.