Objective: To evaluate the role of clinical and paraclinical features in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: Five patients (3 men and 2 women) fulfilling the diagnosis criteria laid by the Ad-hoc Subcommitee of American Academy of Neurology 1991) for the CIDP, were examined clinically and paraclinically. Results: One had a relapsing and others a progressive course over at least 6 months. A history of previous infection was give 1 patient. Weakness and sensory impairment were presented in all cases. Cranial nerves were involved in 3 patients. Cerebrospinal fluid (CSF) study showed a raised total protein count in 4/5 patients with cells 10/mm3. Electrophysiological studies revealed a slowing down of nerve conduction velocities (NCV) to an extent compatible with a demyelinating process in all cases. Central nervous system (CNS) demyelinisation associated with ClDP was found in 2 patients through evoked potentials and MR!. Conclusion: History, clinical findings, CSF and NCV studies were used as the basic of diagnosis of ClDP. Both CNS demyelinisation and CIDP may occur repeatedly and simultaneously as a result of common immunopathogenic mechanism.
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