The purpose of the study was to evaluate the efficacy of vascular outcomes and the relation to clinical outcomes after 3 months and intracranial hemorrhage complications after 24 hours. The study population was composed of 62 ischemic stroke patients with middle cerebral artery occlusion treated with intravenous alteplase thrombolysis within 270 minutes from onset at the Emergency Department - Bach Mai Hospital from 12/2009 to 7/2013. The rate of cerebral vascular recanalization was 61.3 percent; After 3 months, good clinical outcome was 21 times higher in group with recanalization when compared with group without recanalization (p 0.001). The intracranial hemorrhage in recanalization group was higher than group without recanalization after 24 hours (p 0.05). The rate of symptomatic intracranial hemorrhage was only 1.61 percent. The good clinical outcome was 43.5 percent. These results showed that treatment with intravenous alteplase in middle cerebral artery occlusion within 270 minutes was effective and safe.
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