Recently, the CC genotype of rs12979860 and the TT genotype of rs8099917 SNPs have been demonstrated association with favorable spontaneous and drug-induced clearance of HCV infection. The distribution of these SNP Alleles varied according to populations. The frequency of rs12979860 and rs8099917 SNP Alleles in Vietnamese CHC patients was almost unknown. The aim of study was to estimate the frequency of these two SNP Alleles in HCV infected patients in Southern Vietnam as well as to compare the results between them. Methods. The authors used TaqMan Realtime PCR technology to determine the Allele frequency of the rs12979860 in 407 patients and rs8099917 in 214 out of these 407 patients. Results. The rs12979860 C Allele frequency was 88,1 percent and the genotypes CC - CT - TT of this SNP were 78,1 percent (318/407) - 19,9 percent (81/407) and 2 percent (8/407) respectively. The rs8099917 T Allele frequency was 87,4 percent and the genotypes TT - GT - GG of this SNP were 79 percent (169/214) - 16,8 percent (36/214) and 4,2 percent (9/214) respectively. For prediction of viral response (major versus minor+ mixed), the concordance between genotypes. of these two SNP were 89,7 percent (192/214). Conclusion. This is the first report providing at the same time the genetic data of the frequency of the two SNP rs12979860 and rs8099.917 of Vietnamese CHC patients. The major Allele of both SNPs were nearly 90 percent and these data were comparable with other populations in the East and South East Asia. The concordance between these two SNPs was 89,7 percent.
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