Đánh giá hiệu quả điều trị hormon GH ở trẻ chậm tăng trưởng chiều cao do thiếu hormon GH tại Bệnh viện Nhi Đồng 2

To describe clinical feature, laboratory indexes, outcomes of patients with growth hormone deficiency (GHD) treated with rhGH and factors affecting the height velocity response at Children’s Hospital 2 from January 2015 to December 2022. Method: A case series study. Results: There were 44 patients with GHD. Male: female ratio: 2.4: 1.0, median age was 10 years old. Height SD before treatment: -2.2 SD. Median height growth rate was 2 cm/year (-3.6 SD). 82% patients had complete hormone deficiency, 65.7% IGF-1 was below -2 SD, difference between chronological ages and bone ages (CA-BA) was 3 years, 34.1% brain MRI was abnormal. Dramatically increased height velocity: 10,5 cm in the first year, height SD increased, CA-BA decreased, IGF-1 levels increased. There was no side effects. A significantly negative correlation was seen between first year change in height and bone age, chronological age at initiation, timing of onset of symptom. Conclusion: Treatment of growth hormone deficiency is effective. The earlier initiation of GH treatment in children with GHD, the better improvement of their height velocity.