Đánh giá hiệu quả ứng dụng kỹ thuật tiêm tinh trùng vào bào tương noãn (IVF/ICSI) trong điều trị vô sinh tại bệnh viện phụ sản Thanh Hóa

Background: Conventional IVF has been applied for infertility treatment in Infertility Department, Thanh Hoa Obstetrics and Gynaecology Hospital since 2007. However, IVF is not working on some of cases related to sperm quality, abnormal fertilization, unexplained infertility or some previous failed with IVF cycles treatment. IVF/ICSI was applied first on April 2010 but for some reasons, this technique has been developed in the year of 2011. The first baby from IVF/ICSI was born on April 2012, weight 3300g. Since then, IVF/ICSI has been widely used most of couples who have been in right indication. Method: This prospective pilot study including total 108 cases IVF/ICSI during the time from 7/2010 - 10/2012 with two objectives: (1) To investigate the success rate of IVF/ICSI for infertility treatment and (2) Explore some factors which can affect the adverse outcome of IVF/ICSI success rate. From which some supports ideas that can contribute to improve the effectiveness of IVF/ICSI for infertility treatment. Results: Among 106 IVF/ICSI cycles, 10 cycles had no embryo transfer due to no embryo, frozen all embryos because of ovarian hyperstimulation syndrome or thin endometrium. Mean number of oocytes retrieved was 7,6 (:+ or - .4,4), rate of oocyte fertilization was 65,6 percent, mean of good or moderate embryos was 4,0 (+ or - 2,7), mean of number embryo transfer was 3,4 ( + or - 1,7), mean of number frozen embryos was 0,6 (+ or - 01,8). Pregnancies rate was 37,5 percent but clinical pregnancy rate was 33,3 percent. Factors affecting the outcome of IVF/ICSI mostly related to the quality of embryos, and the most important was fertilization rate due to the skill of ICSSI experts. Some solutions have been considered to improve the clinical pregnancy success rate as the skill of ICSI experts, technique of sperm selection, providing more oocyte retrieved within an ovarian stimulation cycle, and applying assisted hatching (AH). Conclusions: The overall this new technique IVF/ICSI in the department was good but the author need to solve some problems above to improve the pregnancy success rate. the author need more studies in these situations.