Đánh giá kết quả điều trị và hiệu quả bảo vệ não của phương pháp hạ thân nhiệt chỉ huy với đích 33°C trong điều trị bệnh nhân hôn mê sau ngừng tuần hoàn

To evaluate the therapeutic and brain-protective effects of the 33°C targetted hypothermia method in the treatment of comatose patients after out-of-hospital cardiac arrest. Subjects and methods: A controlled intervention study on 136 comatose patients after out-of-hospital cardiac arrest who were successfully resuscitated with return of spontaneous circulation, 68 patients received 33°C target hypothermia, 68 patients Retrospective control group routine treatment at A9 emergency department, Bach Mai Hospital from January 2013 to January 2020. Results: Survival was higher in the 33°C target hypothermia group than in the control group at discharge (58.8% vs 33.8%; p= 0.003) as well as at 6 months (51.5% vs 10.3%; p < 0.001). The good neurological outcome was higher in the hypothermic group than in the control group at 30 days (36.7% vs 10.3%; p < 0.001) as well as at 6 months (39.7% vs. 3%; p<0.001). Conclusions: Targeted hypothermia treatment of 33°C improves survival as well as good neurological outcomes for comatose patients after out-of-hospital cardiac arrest.