Objectives: (1) to determine serum vitamin 25(OH)D3 level and (2) to determine relation between vitamin 25(OH)D3 level and other factors in patients with knee osteoarthritis at Bach Mai hospital. Patients and Methods: cross-sectional study included 70 patients with osteoarthritis (ACR 1991 criteria for osteoarthritis) at Bach Mai hospital from 7/2012 to 10/2013. Patients haven't been diagnosed knee osteoarthritis and haven't been treated osteoarthritis and osteoporosis before administration. All patients were examined and recorded body mass index (BMI). Knee radiograph$ were given scores for global severity of osteoarthritis, using a modification of the scale of Kellgren and Lawrence (range, 0 to 4). Serum concentration of vitamin 25(OH)D3 was measured by the Electrochemiluminescence immunoassay on the Roche Elecsys system (Roche Diagnosis Elecsys). Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometry (DEXA) test. Result: Study included 70 patients (16 men 23 percent and 54 women -70 percent). (1) Mean serum vitamin 25(OH)D level was 26,01 + or - 6,7ng/ml. There was 67,1 percent patients had serum vitamin 25(OH)D 30ng/ml. (2) The serum vitamin 25(OH)D3 in the group below the age of 65 was 28:7,9ng/ml, (lnd that in the group above the age of 65 was 24,7:5,6ng/ml, p0,05. The serum vitamin 25(OH)D3 in the group having one osteoarthritis knee was 27:6,2ng/ml, and in the group having both osteoarthritis knees was 23,3 + or - 7,3ng/ml (p0,05). The serum vitamin 25(OH)D3 in patients having stage 2 osteoarthritis was higher than in patients having stage 3 (p0,05)knee. There was positive association with femoral neck T-score (r
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