Giá trị Oxit Nitric khí thở ra trong chẩn đoán và theo dõi điều trị hen phế quản ở trẻ em

The objective of this study was to evaluate the value of FeNO for the diagnosis and treatment of children with asthma. This was a prospective, longitudial study for 6 months of children aged between 6-15 years old who were diagnosed the first time with asthma. Each child was invited to participate in 3 visits (initial visit, 2nd visit after 3 months and 3rd visit after 6 months). At each visit, patient completed the asthmatic questionnaires, clinical examinations and pulmonary function tests were performed and FeNO level was measured. 50 asthmatic children and 30 healthy children were eligible to participate in this study. The concentrations of FeNO of children with asthma was higher than that of heathy children (23.43ppb compared to 8.75ppn, p < 0.05). FeNO concentrations decreased significantly after 3 months and 6 months of using prophylaxis (23.43ppb compared to 14.5ppb and 14.63ppb, respectively; p < 0.05). FeNO level reflected the asthma control over time. Conclusion FeNO measurement is a non-invasive method to assess airway inflammation and the effectiveness of treatment in children with asthma.