Kết cục thụ tinh ống nghiệm của các trường hợp có sự không đồng bộ giữa AMH và AFC trong tiên lượng đáp ứng kém

Anti-Mullerian Hormone (AMH) correlates well with antral follicle count (AFC) and with the number of oocytes retrieved. In some circumstances, there is a discordance between AMH and AFC in predicting poor response. We want to investigate which biomarker has better predictive value in predicting poor response. Objectives: To compare the predictive value of AMH and AFC to predict poor response in patients having a discordance between AMH and AFC in predicting poor response. Method: A retrospective cohort study was conducted at IVFMD, My Duc Hospital, Ho Chi Minh City. Eligible patients had a discordance between AMH and AFC in predicting poor ovarian response. Poor ovarian response was defined as ≤3 oocytes retrieved, or no oocyte retrieved or no developing follicle. Results: F-rom January 2016 to December 2019, a total of 1219 patients were recruited to the study. AMH has a better predictive value as compared to AFC in predicting poor ovarian response, including no developing follicle (AUC = 0.76 versus AUC = 0.53, p <0.001) and no oocyte retrieved (AUC = 0.73 versus AUC = 0.50, p <0.001). Conclusion: In patients having a discordance between AMH and AFC, AMH has a better predictive value than AFC in predicting no developing follicle and no oocyte retrieved.