Kết quả điều trị trẻ mắc hội chứng thận hư tiên phát kháng thuốc Steroid bằng Cyclosporin A tại Bệnh viện Nhi Trung ương

This paper describes the clinical, paraclinical features and the outcomes of cyclosporine A treatment in children with steroid resistant nephrotic syndrome. Subjects and methods Descriptive prospective study enrolled 75 children with steroid resistant primary nephrotic syndrome, hospitalized at the Department of Nephrology-Dialysis, the Hospital of Paediatrics f-rom January 2015 to December 2015. Results 61.3% of the patients showed early resistance and 38.7% of the patients with late resistance. The most common clinical symptoms were edema - 100%, chronic renal failure - 12.0%, hematuria - 10.6%, and hypertension - 9.3%. A renal biopsy for 34 patients showed that 70.6% of these were with focal and segmental glomerulosclerosis (FSGS), 26.5% with minimal change disease (MCD), and 4.9% with diffuse fibrosis. After a 6-month cyclosporine A treatment, the proportion of response was 81.3%, of which, 69.3% showed complete remission and 12.0% with partial remission; but after 12 months, the given percentages gradually decreased. There were 8 end-stage renal disease patients (10.7%) died. Conclusion Steroid resistant nephrotic syndrome in the children expressed very severe clinical symptoms and the mortality rate was high.