Kiểu gene virut viêm gan B liên quan với đặc điểm lâm sàng, cận lâm sàng ở người mang virut không triệu chứng và bệnh nhân ung thư gan

Aims: to investigate the distribution of HBV genotype and it's role in patients with hepatocellular carcinoma (HCC) and asymptomtic chronic HBV carriers (ASYM). Patients and methods: 54 HBV infected patients with HCC and 54 ASYM were enrolled in this study. HBV DNA was measured by Real Time PCR using Taqman prob, HBV genotype was detected by restriction fragment length polymorphism (RFLP) PCR and sequencing. Results: there are 5 single genotype (B, C, D, E, F) and 5 HBV genotype mixture (BC, BD, BE, CE, CE) have been found; among them genotype C, BC and CE are predominant (64,8 percent, 12.9 percent and 11.1 percent, respectively). HBV genotype mixture in HCC group has been found more frequent in comparison to ASYM (OR = 2.94 (95 percent [1. 1-8. 23], P 0.05; Chi 2(1)