Studying on insulin resistance of 124 type 2 diabetic mellitus with kidney lesion compared that of 113 type 2 diabetic mellitus without kidney lesion and of 51 healthy people, and relation between insulin resistance with level, stage of chronic kidney disease of type 2 diabetic mellitus with kidney lesion, the results show that: Insulin Resistance Index of type 2 diabetic mellitus with kidney lesion is 3.76 + or - 2.08, higher significantly than that of typ 2 diabetic mellitus without kidney lesion (2.83 + or - 1.81); of healthy control (1.43 + or - 0.49), p 0.01. The authors not find significant difference of insulin sensitivity, beta cell function between patients of type 2 diabetic mellitus with or without kidney lesion, p 0.05. The authors also find a negative correlation between insulin resistance; positive correlations between insulin sensitivity; beta cell function and glomerular filtration rate of type 2 diabetic mellitus with kidney lesion, r= - 0.39; 0.41; 0.43, P 0.05.
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