Mối liên quan giữa kiểu hình miễn dịch CD44, ALDH với đặc điểm nội soi và mô bệnh học trong ung thư biểu mô tuyến dạ dày

To analyze the relationship between CD44 ALDH immunophenotype, with endoscopic and histopathological characteristics in gastric adenocarcinoma. Subject and Method: This was cross-sectional descriptive study; prospective design on 121 patients with confirmed diagnosis of gastric adenocarcinoma and surgical resection of the tumor at K Hospital. Analysis of the relationship between CD44, ALDH and parameters. Result: Patients with ulcerative tumors had a higher CD44 expression rate with 86.7%, p>0.05. Patients with intestinal tumor had a higher CD44 expression rate with 67.5%, p>0.05. Patients with tumor size from 2 to < 5 cm had the highest ALDH expression rate with 77.0%, p < 0.05. Patients with poorly differentiated tumors had the highest ALDH expression rate with 58.1%, p<0.05. Patients with stage III tumor had the highest ALDH expression rate with 71.6%, p<0.05. Conclusions: CD44 expression tends to be higher in ulcerative and intestinal forms. ALDH expression differs according to endoscopic tumor size, differentiation, and disease stage.