Mối liên quan giữa mức độ biệt hóa tế bào gan với một số chỉ số cận lâm sàng ở bệnh nhân ung thư biểu mô tế bào gan nhiễm virut viêm gan B

Background: Differentiated grade is associated with malignancy of hepatocellular carcinoma (HCC). Aims: to evaluate the relationship between differentiated grade with laboratory parameters in HCC patient infected with hepatitis B virus (HBV). Patients and methods: 77 HCC patients with HBV were diagnosed based on cytology and divided into well (n=17), moderated (n=49) and poor differentiated (n=l1). HBV DNA was measured by using Taqman Prob principle. Result: The poor differentiated group was younger, with lower hemoglobin and prothrombin, but higher total Bilirubin in comparison with moderated and well differentiated groups (p 0.05). 30/77 (38.69 percent) patients have AFP 200 U/L; in contrast, there are 47/77 (61.04 percent) patients having AFP 200 U/L, there are only 11.77 percent of patients in well differentiated group having AFP 200 U/L. HBV DNA in poor differentiated group was significantly higher compared with the well differentiated group (1.9 x10 exponent 8 + or - 2.9 x 10 exponent 8 vs 7.9 x 10 exponent 7+ or - 2.1 x 10 exponent 8 copies/ml, p 0.05). Conclusion: differentiated grade is associated with age, HBV DNA and liver damage, but not associated with number and size of tumor and sex.