Background: Leukostasis is a common complication of hyperleukocytic ALL. Purpose: To assess effectiveness of leukapheresis in term of reduction of WBC and some biochemistry indicators in hyperleukocytic ALL. Patients and methods: Study was carried out on 25 ALL patients treated with leukapheresis using COBE SPECTRA apheresis machine in NIHBT from 2/2011 to 1/2012. Results: (1) Change of WBC and other peripheral blood indicators after leukapheresis: (a) WBC reduced significantly right after leukapheresis and after 24 hours (with values of 306, 208 and 187 x 10 exponent 9/L, respectively) (P0,01); (b) Cytoreduction effectiveness right after leukapheresis and after 24 hours are: 32.1 percent and 38.9 percent, respectively; (c) Hemoglobin concentration reduced after leukapheresis (79 and 68 g/L, respectively) with P0,05. (2) Change of blood uric acid and LDH after leukapheresis: (a) Uric acid concentration reduced significantly (P0,01) (values before and after leukapheresis are: 412 and 359 IJmoi/L for males; 313 and 236 IJmoi/L for females); (b) LDH concentration reduced significantly (values before and after leukapheresis are 2958 and 1367 U/L) (P0,01). Conclusion: Leukapheresis is an effective supportive treatment for hyperleukocytic ALL in term of reducing WBC, blood uric acid and LDH.
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