Base: The increase of phosphatsse alkaline concentration related with bone damage, heart disease and mortality in patients with chronic renal failure. Purpose: Research alkaline phosphatase levels and the correlation between alkaline phosphatase and calcium, phosphorus, parathyroid hormone and bone mineral density in patients with chronic renal failure. Subjects and Methods: 126 patients. of chronic renal failure, 96 male and 30 female, mean age 54.7 + or - 13.3, treated at 108 hospitals from 2/2006 - 10/2008, the dialysis patients were divided into two groups. Group 1: 91 patients with chronic renal failure not on dialysis (Grade 1,2,3). Group 2 included 35 patients who had renal dialysis cycle (Grade 4.5). All patients were clinically examined, blood tests: urea, creatinine, alkaline phosphatase, phosphorus, total calcium, serum hormone parthyroid, bone density measured by DEXA method, positions measured at the femoral neck and lumbar vertebrae. The statistical data were processed on SPSS 15.0 software. Conclusion: - ALP levels in groups of patients with dialysis increased higher than that in patients without dialysis (314.66 + or - 306.87 compared with 198.84 + or - 105.01, P 0.0001). Percentage of patients with increased ALP levels exceed the permissible limits of this group also may be higher than that in the group without dialysis (34.3 percent compared to 9.91 percent, p 0.001).- There is positive correlation between levels of ALP at a concentration of serum calcium and PTH (r
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