Background: The concentration of BNP and NTproBNP are known and significant increase in diagnosis, prognosis in hearl failure. They also increased the pathologic stage of cerebral hemorrhage. Ojectives: To determine whether NTproBNP concentrations are increased in patients's plasma during acute cerebral hemorrhage and its relationship with the severity of the disease. Subjects and Methods: The study on 30 patients with acute phase cerebral hemorrhage at the Department of reanimatio and emergency, Hue Central Hospital. Patients were diagnosed based on clinical symptoms and CT scan's images of the brain, NT-proBNP testing for 24-36h after admission, severity of illness based on the Glasgow scale and injury on brain's CT scan. Results: The concentration average of NTproBNP plasma of research group was 485.36 + or - 396.87 pg/mI. It has increased significantly compared with the control group. Level of plasma NTproBNP associate with severe state of cerebral hemorrhage. Plasma NT-proBNP have positive corralation with systolic blood pressure (r=0.31) and diatolic blood pressure (r=0.21), negative corralation with Glasgow coma scale (r=-0.49) and blood sodium (r=-0.15). Conclusion: NT-proBNP concentrations increased in plasma of patients during the acute cerebral hemorrhage. It is related to a number of factors such as age, sex, Glasgow scale, the number of erythrocytes, hemoglobin, hematocrit, blood creatinine, blood glucose. However, the prognostic value of it should be studied further.
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