Uremic neuropathy is a common complication in patients with end-stage renal disease. The electrophysiological study is a sensitive test for diagnosis of neuropathy in these patients. Objective: To describe and compare a electrophysiological neuropathy in the patients with chronic renal failure pre-dialysis (CRF stage-5) and the patients on hemodialysis (HD). Methods. Electrophysiologic investigations in the sural, peroneal, median and ulnar nerves were performed in 197 uremic patients (102 of CRF stage-S and 97 of HD group) and 90 healthy. Result: The number of patients with slowing of nerve conduction velocity in the sural and peroneal nerves were increased 2.97 times and 1.44 times respectively when the creatinine clearance falls to 12 mL/min. Compared with normal control, the nerve conduction velocity and amplitude and distal latency of all tested nerves decreased significantly in the patients with endstage renal disease (p 0.05). The differences between CRF stage-5 and HD group were the nerve conduction velocity, distal latencies and amplitude of the sural and median nerves (p 0.05). However, the amplitude did not differ on the sural and ulnar nerves between CRF stage-5 and HD patients (p 0.05). Hoffmann reflex measurement was also significantly differentiated between two groups (p 0.05). Conclusion: In the end-stage renal disease, the neuropathy usually parallels the creatinine clearance falls to 12 mL/min. After hemodialyse, the nerve conduction velocity was significantly improved in the median and sural nerves, but no significant improved in amplitude of the peroneal and ulnar nerves.
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