Allergic rhinitis is one of allergic respiratory disease common in ENT and allergy specialist, the cause is mainly due to house dust mites Dermatophagoides pteronyssinus. Immunotherapy is the treatment according to the pathology, which changes the natural progression of allergic disease, to be effective. Immunotherapy sublingual formally applied in the world since 1998 and the World Health Organization has recommended that all countries should adopt alternative injection. Subjects and Methods: 45 patients with allergic rhinitis due to house dust mite immunotherapy D. pteronyssinus be specific sublingual and evaluate the change over tests in vivo and in vitro. Results and discussion: After 24 months of treatment skin test negative 24.44 percent, no level 4 (+ )-negative rate of nasal stimulation test is 15.56 percent, no degree 3 (+) and 4 (+) patients had reduced levels of response, which is 2 levels decreased the most (55.55 percent), white blood cells react and degrade specific mastocyte much reduced both in number of positive and the positive degree. Conclusion: Specific immunotherapy sublingual impact on reducing the pathology status destroying mast cells, limiting the inflammatory mediator... to change the tests in vivo and in vitro. This suggests that the specific immune therapy with allergens D. pteronyssinus also positive results.
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