Pulmonary disorders are currently the major cause of morbidity and mortality in systemic sclerosis. The purpose of the study was to explore the characteristics of clinical and sub-clinical scleroderma with interstitial pulmonary disease. Methods: A cross-sectional study was conducted in 37 patients diagnosed with systemic sclerosis from November to August at the Center for Allergy and Clinical Immunology, Bach Mai Hospital. Results: Clinical symptoms are shortness of breath, dry cough, chest pain, fever and rale. Subclinical sign from high - resolution computer tomography (CT scan) shows 84 percent of the study population has interstitial lung disease, 45.9 percent has mixed disorder lung function and 21.6 percent has restrictive disorder; most of them are mild and moderate. There is a significant correlation between interstitial lung disease and FVC, FEV1, anti-topoisomerase antibodies (anti - Scl - 70). Conclusions: Interstitial lung disease is a common disorder in systemic sclerosis. the authors found a strong association between restrictions in pulmonary lung function and positive anti - topoisomerase antibodies.
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