A total of 807 samples were collected from Pediatric Hospital in Thai Binh, September 2010 - September 2012, among which 90 percent were under the age of 3 years. Overall detection rate for rotavirus, norovirus and E.coli were 40 percent,43 percent and 15 percent, respectively. Co-infection with 2 or 3 pathogens occurred in 20 percent of the cases, of which RV-NV are the most common co-infection (8.8 percent). RV genotype G1P[8] continued to dominate during the 2 years, accounting for 70 percent of the circulating strains. Meanwhile, G3 genotype diminished and only 1 case was identified in 2012. A single case of G9 was detected. Overall, NV GII.3 and GilA represent 27 percent and 59 percent of the strains, respectively. However in 2012, GII.3 tends to dominate over GilA. Antigenic drift in GilA genotypes was observed in which the Minerva! 2006 variant gradualy reduced while Aperldorn/2010 variant sustains and Sydney 2012 emerged. A single case of recombinantion between GII.3 and GilA was identified. The continuing evolve of the genetic make-up of these most important viruses emphasize the need of contiuing surveilalnce, for appropriate vaccination stratergies as well as monitoring of strain diversity after mass vaccination.
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