Purpose: Evaluate effect of GPA software to follow-up glaucoma progression and recommend target lOP of different stage. Patients and Method: 154 eyes of 96 primary open angle glaucoma patients with treated glaucoma were prospectively enrolled and subjected to automated perimetry every 3months in 9 months. Visual acuity, intraocular pressure (lOP), retinal nerve fiber layer (RNFL) thickness was recorded. The patient had completed at least 5 visual field tests, including the 2 baseline visual field and 3 test follow-up. MD, PSD, VFi, GPA progression symbols were recorded. Glaucoma progression was identified according to Early Manifest Glaucoma Trial criterion using Glaucoma Progression Analysis software. Possible progression required at least 3 test points deteriorated p0,5 repeated in 2 visual field tests. Likely progression required at least 3 test points deteriorated p0,5 repeated in 3 visual field tests. In case unable evaluate by pattern deviation, defined progression if VFi had significant reduction with rate of progression. lOP of no- progression was recorded in different stages. Results: After 3 months, had no-progression. After 6 months, 1 eye had possible progression with 3 depressed test points. After 9 months, 3 eyes had possible progression (2 eyes had 3 depressed test points, 1 eye had 4 depressed test points). 4 eye had significant reduction of VFi. All of 7 cases lost of RNFL but less than 20pm and lOP were higher than 18mmHg in every exam. No progressive eyes had no significant difference in MD, PSD, VFi, RNFL thickness and target lOP of mild, advanced, serious, near end stages were 17.8 +/- 1.4, 16.4 +/- 1.3, 15. 1 +/- 0.8, 14.5 +/- 0.9 mmHg. Conclusions: GPA software detected glaucoma progression accurate and objective. After 9 months, progressive incidence was 4.5 percent. The lower target lOP is, the later stage is.
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