Vai trò của IgA, IgG và IgM huyết tương trong dự báo đáp ứng điều trị ở người lớn mắc hội chứng thận hư nguyên phát

Determination of the predictive value of non-response of plasma IgA, IgG and IgM levels to corticosteroid therapy in adults with primary nephrotic syndrome (NS). Subjects and Methods: Longitudinal follow-up study on 57 patients diagnosed with primary NS. Assessment of response to treatment was based on 24-hour proteinuria during the course of treatment. Plasma IgA, IgG and IgM concentrations were determined by ELISA method, at day 2 of the admission. Results: After treatment, the median 24-hour proteinuria decreased significantly compared to before treatment, p<0.001. There were 19.4% of patients did not respond to corticosteroid treatment. The group of non-response patients had serum ure, creatinine higher, glomerular filtration rate lower than those of the response group, p<0.05. There was no difference in IgA, IgG and IgM concentrations between responders and nonresponders, p>0.05. Conclusion: Plasma IgA, IgG, and IgM are not predictive of response to corticosteroid therapy in adults with primary nephrotic syndrome.