Vai trò của tiểu cầu, tỷ lệ AST/ALT, APRI, FIB4 trong đánh giá tình trạng xơ gan hóa

In an attempt to overcome limitations of liver biopsy, several non invasive tests have been developed to assess hepatic fibrosis. The aim of our study was to evaluate the diagnostic accuracy of platelet, AST/ALT ratio, APRI, FIB4 for the assessment of hepatic fibrosis by comparison with liver biopsy. On histological ground: Fa: 19, F1: 16, F2: 12, F3: 13 ,F4: 9. A significant correlation was seen between change in stage of fibrosis and change Platelet (r = - 0.408), APRI (r = 0.55) and a change of FIB4 (r = 0.36). APRI 1.7 and FIB4 2.5 ruled out significant fibrosis in 67.4 and 63.3 percent. More accurately, Platelet 149, APRI 0.7 of FIB4 3.3 ruled out cirrhosis in 83.9; 90.1; 87.3 percent. The AUROC of AST/AL T ratio, APRI, FIB4 to predict significant fibrosis were 0.49; 0.81; 0.72. The AUROC of platelet, AST/ALT ratio, APRI, FIB4 to predict cirrhosis were 0.71; 0.58; 0.8; 0.78. In conclusion, Platelet, APRI, FIB4 were simples and non invasive biochemical markers to predict the presence or absence of liver fibrosis and cirrhosis with AUROC 0.7.