Vi thẩm tách nội hộp sọ cho phép đánh giá thực tại độ tập trung ngoại bào của dẫn truyền thần kinh

Intracerebral microdialysis enables in vivo assessment of extracellular concentrations of neurotransmitters. A probe with semi-permeable membrane is implanted into a specific brain area and, after diffusion and equilibration with intracellular medium, samples can be collected and analyzed. This review describes the fundamental principles of intracerebral microdialysis allowing the collection of neurotransmitters-containing dialysates and its application in the field of neuropsychopharmacology. The limits of this experimental approach will be also discussed.