Đặc điểm bệnh u nguyên bào gan và kết quả điều trị ở trẻ em tại Bệnh viện Nhi Đồng 2

To determine the epidemiological, clinical, paraclinical characteristics and evaluate the result in treatment of hepatoblastoma (HB) at Department of Hematology-Oncology, Children’s Hospital 2 from January 2011 to end of May 2019. From January 2011 to end of May 2019, there were 67 patients diagnosed with HB. The mean age at diagnosis was 22.7 ± 22.9 months with the most prevalent age group ranging from 6 months to 3 years. The male to female ratio was 1.8/1. The most common clinical symptoms were abdominal distention and hepatomegaly, approximately 7.5% HB cases were detected accidentally by ultrasound. Nearly 60% and 80% patients presented with anemia and thrombocytosis at admission, respectively. Almost tumors were unifocal locating in the right lobe of the liver and 58.2% cases belonged to standard risk group. Assessing treatment protocol in 54 HB patients demonstrate that number of patients undergoing hepatectomy after preoperative chemotherapy accounted for 82%. The most frequent acuteside effects after chemotherapy were myelotoxicity and infection. The proportion of fatal and relapsed cases was 31.5% and 12.9% respectively. Overall and event-free survival rate of the study after 3 years was 65.7% and 68.1% individually.