The objective was to study the clinical and laboratory characteristics of mixed connective tissue disease (MCTD). It was a cross-sectional descriptive study. There were 45 patients who were diagnosed as having mixed connective tissue disease from 7/2010 - 7/2012 at the Allergy and Clinical Immunology Center in Bach Mai Hospital, MCTD was diagnosised by using Alarcon-Segovia (1987) criteria. Arthralgia was the most obvious symptom that was seen, 100 percent patients; following by Raynaud syndrome, 93.3 percent. The most common symptoms were muscle pain (86.7 percent), loss of skin wrinkles (82.2 percent), difficulty breathing and chest tightness (88. 9 percent) and muscle damage, 71.1 percent. In the study, the high concentration of autoimmune antibodies was seen in most patients, ANA (Antinuclear antibodies) was 97.8 percent; anti-RNP70 (Anti Ribonucleotidprotein 70) was 100 percent. Interstitial pneumonia and pulmonary artery pressure was seen in many patients. In conclusion, MCTD had overlapping clinical lesions of other autoimmune diseapes; had high titer ANA; had high titer anti-RNP70. There are 64.5 percent patients with interstitial lung injury and PHA 89.3 percent of patients received an echocardiogram.
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