Đánh giá hiệu quả của hóa xạ trị ung thư phổi không tế bào nhỏ giai đoạn III không thể phẫu thuật được bằng kỹ thuật VMAT

Evaluating the effectiveness of chemotherpy and radiotherapy for inoperable stage III lung cancer by the VMAT technique at Cho Ray Cancer Center. Materials and methods: Retrospective analysis of inoperable stage III lung cancerpatients diagnosed and treated between Jan-01-2019 toDec-31-2021 was performed. Results: 84.4% are men, the average age is about 62 years old, and the majority are stage IIIB.28.1% used PET/CT for diagnosis,53.1% of these cases were adenocarcinomas, 60% of patients underwent EGFR mutation testing, however the majority of results were negative (15.6% positive). 43.8% of cases was progressed, with roughly 97% of those being distant metastases(18.8% of which are limited to the brain and 78.1% of which spread to other sites). The mean progression-free survival is 24.04 ± 3.1 months. The disease-free survival rate at 6 months is 84.1%, 12 months is 60.1%, 24 months is 50.7%, 36 months is 33.8%. The parameters at the tumor are similar to the 3D-CRT technique, which has the advantage of limiting the dose to organs at risk (heart, lungs, spinal cord, and esophagus). Conclusion: Using a variety of modalities to combine radiation and chemotherapy produces comparatively good results. The VMAT technique of radiation therapy considerably lowers the dose to organs at risk while achieving good parameters at the tumor.