Background: Oral anticoagulation in the INR target is essential for pts with mechanical heart valve replacement (MHVR). Objectives: l/ To evaluate the contraints of classic model of anticoagulation management; 2/ To identify the rate and the risk factor of the anticoagulation-related complications. Patients and method: observational and analytical, cross-sectional study in 200 pts with MHVR. Results: INR target in 30-33 percent pts and TTR 36.6 percent. Complication includes 18-23.6 percent bleeding and 5-7.5 percent thrombosis, leading to 5 deaths and 8 MHV malfunction. The untargeted INR gives OR 18.46-18.76. Condusion: The out-of- target range INR is relevant to dassic model of anticoagulation management and an important risk factor of cx:rnplication.
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