Objectives: Evaluation of effects of lercanidipine versus amlodipine in patients with cerebral ischemic stroke having hypertension by ambulatory blood pressure monitoring (ABPM). Subjects and methods: 104 patients who had the mean blood pressure 24h or = 130/90 mmHg received antihypertensive treatment and were divided randomly in two parallel groups study, 52 patients (mean age 64.6 years) received the lercanidipin 20 mg/day and 52 patients (mean age 65.4 years) received amlodipine 10 mg/day. After 4 weeks, the 'patients of two groups were taken second measurement in mercury sphygmomanometer to evaluate the effects of drugs. Results: Antihypertensive effect of lercanidipine is the equivalent ofamlodipine on clinical blood pressure in patients having an ischemic stroke with hypertension that expressed as blood pressure decreased by 21.8 percent 21.2/8.9 + or - 14.0 mmHg versus 23.8 + or - 24.5/14.6 + or - 18.3 mmHg (p 0.05). The rate of side effects of lercanidipine significantly lower than with amlodipine (5.7 percent vs. 19.2 percent, p 0.05). Conclusions: Antihypertensive effect of lercanidipine is the equivalent of amlodipine on clinical blood pressure in patients having an ischemic stroke with hypertension. The rate of side effects of lercanidipine significantly lower than with amlodipine. Shoud use lercanidipine in patients having an ischemic stroke with hypertension.
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