Hiệu quả cắt cơn gò tử cung của nifedipine trong điều trị dọa sinh non tại Bệnh viện Từ Dũ

Preterm labor is a global issue. Effective management of threatened preterm labor (TPL) is the key strategy to reduce preterm labor. The protocol for using Nifedipine in the management of TPL has been modified, yet, there is no study investigating this modified protocol at Tu Du Hospital. Objectives To determine the rate of pregnancies prolonged ≥ 48 hours after using Nifedipine in pregnant women diagnosed with TPL between 28 to 34 weeks of gestation. Method A retrospective case-series was conducted at Tu Du Hospital, Ho Chi Minh City from 01/01/2018 to 31/12/2019. Eligible patients were pregnant women who had their pregnancies in between 28 to 34 weeks of gestation, diagnosed with TPL and treated with Nifedipine. The primary outcome was the rate of pregnancies prolonged  48 hours. Results A total of 421 pregnant women was recruited to the study. Mean gestational age at starting Nifedipine was 31.7±2.84 weeks. The rate of pregnancies prolonged  48 hours in women diagnosed with TPL treated with Nifedipine was 80.3% (95% CI 76.6-84). The side effects occurred in 4.04% women and rate of women with CTG group II and group III during treatment was 2.14%. Conclusion Nifedipine is effective and safe for treatment of TPL in pregnancy of 28-34 weeks of gestation.