Antibiotic-associated diarrhoea (AAD) cause by an imbalance in the gut microbiota after using broadspectrum antibiotic therapy. The management of AAD is usually discontinuation or replacement of the causing antibiotic with another drug with lower AAD risk. Another approach to AAD treatment or prevention is based on the use of probiotic microorganisms, capable of re-establishing the equilibrium of the intestinal ecosystem. Several organisms have beep used in the treatment or prophylaxis of AAD such as selected strains of lactic acid bacteria such as L. acidophilus, L. bulgaricus and B. longum. In this work the authors investigate the use of spores of carotenogenic Bacilli isolated from Vietnam for treatment of AAD in a mouse model. The results showed that although lack of many probiotic characteristics such as pathogen antagonism, antimicrobial producing ability like lactic acid bacteria, carotenogenic Bacilli can effectively stop diarrhoea in the tested mice.
- Đăng nhập để gửi ý kiến