Objectives: The purposes of this study were to measure the value of average velocity of shear wave in liver's parenchyma of patient with chronic liver disease by using acoustic radiation force impulse imaging (ARFI) and to investigate the correlation between shear wave velocity and degree of hepatic fibrosis according to Metavir classification. Methods: 241 of healthy volunteers with normal liver function test values and 160 patients, diagnosed of chronic liver disease based on serologic test of hepatitis and history of alcoholic abuse, were selected for the study. Among these patients, there are 23 patients having histologic results for grading hepatic fibrosis based on Metavir classification. Shear wave velocity measurements, expressed in meters per second, were taken in liver segment 7 or 8 at deepth from 3 to 4 cm below the body surface. Results: The value of average velocity of shear wave in the healthy's liver is 1,05 + or - 0,092 m/s. The value of average velocity of shear wave in the healthy's liver is 1,97 + or - 0,59 m/s. There is statistically significant difference in shear wave velocity between two groups. In term of interobserver results, there is in shear wave velocity obtained by two observers with different levels of experiences (P .001). Conclusions: Velocity of shear wave in liver's parenchyma of patient with chronic liver disease measured by using ARFI increase significantly. There is closed correlation between shear wave velocity in liver s parenchyma and degree of hepatic fibrosis based on histologic results.
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