Nuchal translucency (NT) is the amount of fluid behind fetus's neck. NT is a physiological feature of the fetus and can be measured from 11-14 week of gestation age. NT play an important part in screening chromosomal disorders. Increase of NT between 11 to 14 week is considered a suggestive signs of chromosomal disorders of the fetus. Objectives: to evaluate the rate of chromosomal disorder of the fetuses with increase of NT. Materials and methods: we measured NT of 250 pregnant women in 11-14 week of gestation. Above 3.0 mm considered not normal. Results: the rate of chromosomal disorder is 32.4 percent in those cases of increase of NT among those trisomy 21 is 12.4 percent, monosomy X is 12 percent, trisomy 18 is 5.6 percent, trisomy 13 is 0.8 percent and stutural disorder is 1.6 percent. With the range from 3.0 to 3.9 mm, the rate of chromosomal disorder is 10.1 percent, 4.0 to 4.9 mm is 29 percent, 5.0 to 5.9 mm is 48 percent and above 6 mm is 64 percent. Conclusion: increase of NT is a suggestive signs of chromosomal disorder. The thicker NT is, the higher risk of chromosomal disorder.
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