Purpose: The aim is to estimate the outcome of SIOP 2001 protocol and ability to apply it in our condition. Method: Apply protocol SIOP 2001 for treatment of all patients met the inclusion criteria of the protocol. Result: From July 2008 to November 2011, The research had 56 patients eligible for enrolment on SIOP 2001 protocol. 42 patients had definitive diagnosis of nephroblastoma with 5 patients had immediate operation and 37 undergone preoperative chemotherapy with their postoperative staging:14 stage I, 16 stage II and 7 stage III. Up to 30th June 2012, 4 patients died, 2 relapsed and 1 abandoned treatment after operation. Imaging diagnosis is corrected with pathological anatomy in 39/50 cases (78.0 percent). The preoperative chemotherapy had effectiveness in down-staging of patients but the result is much lower than expected: 37.8 percent in stage I, when previous SlOP studies showed around 60 percent. 8 patients (19 percent) received Doxorubicin and radiotherapy. There are 85.4 percent of patients in EFS (follow-up time from 6 to 46 months, mean 26 months). Conclusion: in NHP protocol SIOP 2001 can be applied and had so far good outcome and long time follow up is required to estimate. the result of treatment.
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