Nghiên cứu một số yếu tố tiên lượng đáp ứng điều tri ở bệnh nhân viêm gan vi rút B mạn HBeAg(+)

Background: The HBeAg-positive chronic hepatitis B patients are patients in immunoclearance phase. Some factors may have influence on treatment response. the authors evaluate some prognostic factors of treatment response in HBeAg-positive chronic hepatitis B patients. Aims: Evaluate some prognostic factors of treatment response in HBeAg-positive chronic hepatitis B patients. Patients and methodes: HBeAg-positive chronic hepatitis B patients over 15 yrs treated at Hue University Hospital from Jan. 2012 to Dec. 2013. Results: Female have higher response than male (RR = 1.338). Patients with higher baseline ALT and lower HBV DNA have higher response than patients with lower baseline ALT and higher HBV DNA (RR = 1.332 and 1.236). Naive patients and patients have response after 3 months have higher response than non-response patients (RR = 1.733 and 1.357). Conclusions: Female, higher baseline ALT and lower HBV DNA before treatment, native patients and patients have response after 3 months were significant prognostic factors.