Disturbance of dopaminergic system induces disorders that influence to the quality of life, such as Parkinson, Alzheimer diseases, schizophrenia, etc. An advanced method to study the role of dopamine receptors is making strains of mice lacking dopamine D1 and D2 receptors. However, knockout of these genes influenced the whole body so determining the role of those receptors on each organ/system is necessary. In order to evaluate the impact of dopamine D1 and D2 receptor knockouts on vestibular and visual systems, this study had been conducted on 30 C57BL6, 11 D1R-KO and 17 D2R-KO mice, aged 10-12 weeks old, weighted 23-26g, by using climbing rod test and visual acuity test to assess vestibular and visual functions respectively. The animals had been supplied by Animal center of Toyama Pharmaceutical and Medical University. The results showed that knockout of dopamine receptor did not cause clearly disorder in activity of those two important systems. In addition, those results also confirmed dopamine having a role in motor activity (via striatum) and motivation (via mesolimbic system).
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