Báo cáo trường hợp trẻ mắc hội chứng Tafro

TAFRO syndrome was first reported in 2010 in Japan. It is characterized by a constellation of symptoms Thrombocytopenia, Anasarca, reticulin Fibrosis of the bone marrow, Renal dysfunction and Organomegaly (TAFRO). Prompt diagnosis of TAFRO syndrome is critical due to its life threatening conditions. Patients with TAFRO syndrome usually respond to immunosuppressive therapy. TAFRO syndrome often occurs in the middle-aged and the elderly, and is rarely seen in adolescents. Here we report the first child case diagnosed with TAFRO syndrome, and successfully treated with Cyclosporin A in the national children hospital. A 6-year-old boy Vietnamese was referred to us with fever. He had edema, dyspnea, anasarca, hepatosplenomegaly, anemia, thrombocytopenia, elevated C-reactive protein and hypoproteinemia, acute renal failure, high proteinuria, slightly decreased C3, normal C4, bone marrow biopsy reveals increased number of megakaryocytes. He was diagnosed with TAFRO syndrome, treated by prednisone 1mg/kg/day combined with cyclosporin A 4mg/kg/day for 2 weeks. Improvement seen with no fever, no edema, increased platelets, and improved kidney function.